Synthesis of Metabolites of the Ah Receptor Ligand 6‐Formylindolo[3,2‐<i>b</i>]carbazole

Abstract

Abstract Synthesis of the five mono‐ and di‐hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6‐formylindolo[3,2‐ b ]carbazole is described. The structures of the metabolites were unequivocally established as 2‐hydroxy‐, 8‐hydroxy‐, 2,10‐dihydroxy‐, 4,8‐dihydroxy‐ and 2,8‐dihydroxyindolo[3,2‐ b ]carbazole‐6‐carboxaldehyde. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)