Nasal‐Associated Lymphoid Tissue and Olfactory Epithelium as Portals of Entry for<i>Burkholderia pseudomallei</i>in Murine Melioidosis

Abstract

These data suggest that the olfactory nerve is the route of entry into the brain and that this route of entry may be paralleled in cases of human neurologic melioidosis. This study focuses attention on the upper respiratory tract as a portal of entry, specifically focusing on NALT as a route for the development of systemic infection via the bloodstream and on the olfactory epithelium as a direct route to the brain.