Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy

Towards a network theory of the immune system.

Jerne Nk · PubMed · 1974 · 3.4K citations

Network Theory, Network Science, Engineering +6

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Julian Gannon, R Greaves, Richard Iggo et al. · The EMBO Journal · 1990 · 981 citations · Full text

Mutant Form, Medicine, Molecular Biology +5

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

Martin L. Smith, I.-Tsuen Chen, Qimin Zhan et al. · Science · 1994 · 948 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

Jiří Bártek, Jiřina Bártková, Bořivoj Vojtěšek et al. · PubMed · 1991 · 510 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

L.V. Crawford, D. Pim, R.D. Bulbrook · International Journal of Cancer · 1982 · 452 citations

Lung Metastases, Oncology, Breast Oncology +13