Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas

Abstract

A few cases had overlapping alterations, and the incidence of one or more RB, p53, or p16(CDKN2) changes appeared to be relatively high in human astrocytomas. These results suggest that cell cycle regulatory gene alterations may play an important role in the development of gliomas.