Concepedia

Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor

Ablajan Mahmut, Marie‐Chloé Boulanger, Rihab Bouchareb, Fayez Hadji, Patrick Mathieu

Cardiovascular Research · 2015 · 46 citations · 31 references

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Abstract

Expression of NPP1 and 5'-nucleotidase by VICs promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway.

References

31

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL

T. Heinemeyer · Nucleic Acids Research · 1998 · 1.5K citations · Full text

<i>NT5E</i> Mutations and Arterial Calcifications

Cynthia St. Hilaire, Shira G. Ziegler, Thomas C. Markello et al. · New England Journal of Medicine · 2011 · 444 citations · Full text

Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine

Akihiko Okawa, Isao Nakamura, Sumio Goto et al. · Nature Genetics · 1998 · 428 citations

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Evaluation and Clinical Implications of Aortic Valve Calcification Measured by Electron-Beam Computed Tomography

David Messika‐Zeitoun, Marie-Christine Aubry, Delphine Détaint et al. · Circulation · 2004 · 377 citations · Full text

Human Degenerative Valve Disease Is Associated With Up-Regulation of Low-Density Lipoprotein Receptor-Related Protein 5 Receptor-Mediated Bone Formation

Frank Caira, Stuart R. Stock, Thomas G. Gleason et al. · Journal of the American College of Cardiology · 2006 · 366 citations · Full text

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