Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) on IL-6, IL-8, and MCP-1 Expression in Human Retinal Pigment Epithelial Cell Line - Concepedia

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Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) on IL-6, IL-8, and MCP-1 Expression in Human Retinal Pigment Epithelial Cell Line

25

Citations

35

References

2005

Year

Xueyun Zhang, Seiji Hayasaka, Zai‐Long Chi, Hu-Shan Cui, Yoriko Hayasaka

Current Eye Research

Abstract

ARPE-19 cells had PACAP receptors mRNA. PACAP inhibited IL-6, IL-8, and MCP-1 expression and protein secretion. Possibly, the effect on cytokines may be via suppression of NF-kappaB translocation.

References

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