PHARMACOLOGICAL INVESTIGATIONS ON FRUITS OF<i>WITHANIA COAGULANS,</i>Dunal

Abstract

Pharmacological investigations with alcoholic extract, total alkaloids and aqueous extract of the fruits of Withania coagulans showed the presence of central nervous system depressant effect characterised by decreased spontaneous activity and potentiation of pentobarbitone hypnosis. However, the extracts showed no analgesic and anticonvulsant activity. In addition, alcoholic extract and total alkaloids showed a significant antiinflammatory effect in acute inflammation induced with egg albumin, subacute inflammation induced with formalin and granulation tissue formation by cotton pellet method.