Glycerol-induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria.

Abstract

The oliguria of acute renal failure has been at- tributed to tubular obstruction (1-12), "leakage" of the glomerular filtrate through rents in the tu- bular wall (13-19), and vascular mechanisms of various types (20-25). In a previous paper, it was shown that the oliguria of mercury-induced acute renal failure in the rat reflects a primary decrease in glomerular filtration rate and cannot be attributed to tubular mechanisms (26). The ap- plicability of these findings to most types of acute renal failure occurring in humans may be ques- tioned, however, because of the very dissimilar etiologies and the known effect of large doses of mercury on the renal circulation ( The pres- ent study concerns the events leading to the de- velopment of oliguria in glycerol-induced hemo- globinuric acute renal failure, a model more closely akin to the syndrome of acute renal failure in man.