Deuterium Labeling by Electrochemical Reactions

Abstract

The extent to which d1‐labeled isomeric anisoles and toluene result from electrolysis of the corresponding iodoaromatics in deuterium‐containing solvent media has been explored. Solvent mixtures of and unlabeled acetonitrile or dimethoxyethane give products of excellent isotopic purity when lithium perchlorate serves as supporting electrolyte. Use of tetraethylammonium as supporting electrolyte cation gives appreciable percentages of unlabeled product.