Direct Nonisotopic Assay of 3-Methylglutaconyl-CoA Hydratase in Cultured Human Skin Fibroblasts to Specifically Identify Patients with 3-Methylglutaconic Aciduria Type I

Abstract

association is independent of the traditional markers of response in multivariate analysis, including ER concentrations. In addition to its predictive value for tamoxifen resistance in recurrent breast cancer, as shown here, the prognostic value of BCAR1 in primary breast cancer has been confirmed separately (L.C.J. Dorssers et al., manuscript submitted). BCAR1/p130Cas has also been associated with malignant melanoma and some types of leukemia (12 ). Recently, overexpression of BCAR1/ p130Cas in vitro was shown to interfere with KAI1/ CD82-mediated suppression of metastasis in prostate cancer cells (15 ). Further evaluation of the role of BCAR1 in various kinds of malignancies and other diseases may benefit from our quantitative detection methodology for BCAR1 protein.