Science · 1972 · 123 citations · 32 references
Life SciencesNeurobiologyNeuroscienceElectrophysiologyNeurophysiologyVisual NeuroscienceNeurotransmissionOptic NerveRetinal Ganglion CellsRetinal NeuroscienceSynaptic TransmissionVisual SystemElectrical StimulationExcitatory Synaptic TransmissionOptic Nerve PhysiologyPostsynaptic InhibitionRetinal PhysiologyRetinal Synaptic TransmissionSynaptic Transmission DisturbanceSynaptic Transmission Modulation
Colchicine, which inhibits axoplasmic transport and induces organelle alterations in nerve terminals, was injected intraocularly in pigeons. Electrical stimulation of the optic nerve yielded normal evoked potentials in retinotectal fibers, whereas postsynaptic responses recorded in the tectum were reduced. Postsynaptic depression suggests a deficit of synaptic transmission, presumably dependent on colchicine interference with migrating material.
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