Applied Physics Letters · 2007 · 28 citations · 12 references
Natural SciencesBioengineeringBiomedical EngineeringBiomedical OpticsBiophotonicsPhotonicsOptical BiosensingOptical ResonatorsOptical TweezersPhotonic MaterialsRefractive IndexBiomolecular DetectionComplex Refractive IndexMicroresonatorsMicrospheresPolystyreneRefractive Index MeasurementTotal Internal ReflectionWhispering-gallery-mode Resonators
Using evanescent field coupling via frustrated total internal reflection, we measured whispering-gallery optical resonances of polystyrene microspheres held in aqueous buffer by optical tweezers, as a function of the distance from the planar coupling substrate. An intrinsic Q factor of 4×106 was found for a microsphere of 30μm diameter, indicating the potential of such microresonators for highly sensitive biomolecular detection. These measurements provide an upper limit of 2×10−7 for the imaginary part of the complex refractive index of polystyrene at 770nm wavelength.
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Protein detection by optical shift of a resonant microcavity
Frank Vollmer, Dieter Braun, Albert Libchaber et al. · Applied Physics Letters · 2002 · 902 citations
Shift of whispering-gallery modes in microspheres by protein adsorption
S. Arnold, M. Khoshsima, Iwao Teraoka et al. · Optics Letters · 2003 · 727 citations