Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis

Clozapine for the Treatment-Resistant Schizophrenic

John M. Kane · Archives of General Psychiatry · 1988 · 4.1K citations

Medicine, Pharmacology, Psychiatry +16

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine

D Mauri-Hellweg, Florence Bettens, Davide Mauri et al. · The Journal of Immunology · 1995 · 348 citations

Life Sciences, Immunology, Pharmacology +13

HLA-B38, DR4, DQw3 and Clozapine-Induced Agranulocytosis in Jewish Patients With Schizophrenia

J.A. Lieberman · Archives of General Psychiatry · 1990 · 210 citations

Medicine, Pharmacology, Psychiatry +17

Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.

Zhichao Liu, Jack Uetrecht · Journal of Pharmacology and Experimental Therapeutics · 1995 · 204 citations

Medicine, Chemistry, Pharmacology +11

CLOZAPINE AND AGRANULOCYTOSIS

J Idänpään-Heikkilä, Eeva Alhava, M. Olkinuora et al. · The Lancet · 1975 · 182 citations