Synthesis and evaluation for diuretic activity of 1-substituted 6-chloro-5-sulfamylindolines

Abstract

The synthesis of a series of 1-substituted 6-chloro-5-sulfamylindolines is described. In the Lipschitz test for diuretic activity, two of the compounds showed significant excretion of urine and sodium and were approximately equivalent in potency to chlorothiazide but with a later onset of activity.