Concepedia

The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis

Ian M. Clark, Liz Powell, SD Ramsey, B L Hazleman, Tim E. Cawston

Arthritis & Rheumatism · 1993 · 163 citations · 30 references

DOI

Abstract

The level of total collagenase in SF is greater in RA than OA, while levels of free TIMP show more overlap between the 2 diseases; this may simply reflect the increased inflammation seen in RA, or it may reflect a different disease mechanism.

References

30

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

J. Frederick Woessner · The FASEB Journal · 1991 · 3.3K citations · Full text

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

A. John Barrett, P M Starkey · Biochemical Journal · 1973 · 1.1K citations · Full text

Tissue Inhibitor of Metalloproteinase (TIMP-2)

William G. Stetler‐Stevenson, Henry C. Krutzsch, Lance A. Liotta · Journal of Biological Chemistry · 1989 · 897 citations · Full text

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Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

Paolo Mignatti, E. Robbins, Daniel B. Rifkin · Cell · 1986 · 750 citations

, , +9

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

Gregory I. Goldberg, S M Wilhelm, Annemarie Kronberger et al. · Journal of Biological Chemistry · 1986 · 637 citations · Full text