Role of Mitochondria in the Generation of Spontaneous Activity in Detrusor Smooth Muscles of the Guinea Pig Bladder.

Abstract

These results suggest that mitochondria have an important role in Ca2+ buffering in bladder smooth muscles. Mitochondrial Ca2+ is presumably supplied by Ca2+ transport from internal stores and also by capacitative calcium entry through nonselective cation channels. Mitochondrial Ca2+ handling may also be critical for the generation of spontaneous activity in detrusor smooth muscle.