Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade.

Abstract

LVH has a pronounced effect on dispersion of refractoriness and repolarization and renders the ventricle more vulnerable to fibrillation. Blockade of the voltage-dependent potassium channel, but not the slow inward calcium channel, narrows the dispersion of recovery of excitability and protects against VF.