Divergent effects of ephedrine and phenylephrine on cardiovascular hemodynamics of near‐term fetal sheep exposed to hypoxemia and maternal hypotension

Abstract

After exposure to hypoxemia and maternal hypotension, ephedrine restored all fetal cardiovascular hemodynamic parameters to baseline. Phenylephrine did not reverse fetal pulmonary vasoconstriction or the relative decrease in the net forward flow through the aortic isthmus observed in fetuses with increased placental vascular resistance. Moreover, fetal left ventricular function was impaired during phenylephrine administration.