Mutational and functional analysis of the neurofibromatosis type 1 ( NF1 ) gene

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

George A. Martin, David Viskoohil, Gideon Bollag et al. · Cell · 1990 · 1K citations

Life Sciences, Genetics, Molecular Genetics +14

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

Roymarie Ballester, Douglas A. Marchuk, Mark S. Boguski et al. · Cell · 1990 · 861 citations · Full text

Life Sciences, Genetics, Molecular Biology +7

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

Gangfeng Xu, Boris K. Lin, Kazuma Tanaka et al. · Cell · 1990 · 693 citations

Life Sciences, Genetics, Molecular Biology +15

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

Tanya Basu, David H. Gutmann, Jonathan A. Fletcher et al. · Nature · 1992 · 669 citations · Full text

Medicine, Cancer Biology, Oncology +17

Somatic mutations in the neurofibromatosis 1 gene in human tumors

Y Li, Gideon Bollag, Robin Clark et al. · Cell · 1992 · 402 citations

Medicine, Genetics, Molecular Genetics +16