Concepedia

The antiarrhythmic and antiinflammatory activity of a series of tricyclic pyrazoles

Journal of Heterocyclic Chemistry · 1976 · 31 citations · 9 references

Concepts

PharmacyMedicinal ChemistryPharmacologySteroid BiochemistryStructure-activity RelationshipsSynthetic Medicinal ChemistryAntiarrhythmic TherapyArrhythmia PharmacotherapyHeterocyclic ChemistryHeterocyclic CompoundsSteroid PharmacologyMedicinal HeterocyclesPyrazole ChemistryPyrazole Synthesis

Abstract

Abstract A series of tricyclic pyrazoles were prepared from intermediates available from steroid total synthesis and tested for antiarrhythmic and antiinflammatory activity.

References

9

Effect of Prostaglandin E2 on Adjuvant Arthritis

Richard L. Aspinall, Peter S. Cammarata · Nature · 1969 · 91 citations

Medicine, Immunology, Pharmacology +14

The influence of dichloroiso-proterenol (DCI) and related compounds upon ouabain and acetylstrophanthidin induced cardiac arrhythmias.

Benedict R. Lucchesi, Harold F. Hardman · PubMed · 1961 · 76 citations

Medicine, Cardiology, Pharmacology +17

Synthesis and Structure of Steroidal Pregn-4-eno- and 5α-Pregnano [3,2-<i>c</i>]pyrazoles. A Novel Class of Potent Anti-Inflammatory Steroids

Ralph Hirschmann, Paul Buchschacher, N. G. Steinberg et al. · Journal of the American Chemical Society · 1964 · 66 citations

Life Sciences, Medicinal Chemistry, Pharmacology +11

The reaction of 1-Fluoro-2,4-dinitrobenzene with some NH-Heterocyclic compounds

JFK Wilshire · Australian Journal of Chemistry · 1966 · 31 citations

Natural Sciences, Chemistry, Organic Chemistry +10

Quinidine Lactate and Gluconate in the Suppression of Ectopic Ventricular Tachycardias Associated with Myocardial Infarction

A. Sidney Harris, A Estandía, Tedroe J. Ford et al. · Circulation · 1951 · 30 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17