Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations

Abstract

Abstract A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non‐metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5:2.5 er ) as well as spirocyclic oxindoles (97.5:2.5 to >99:0.5 er ), containing all‐carbon quaternary centers, in a highly enantioselective fashion via a one‐pot dynamic relay process. magnified image