Total Synthesis of Marinoquinoline A Using a Palladium(0)‐Catalyzed Ullmann Cross‐Coupling Reaction

Abstract

Abstract The title natural product, 1 , has been synthesized. The pivotal steps are a Pd 0 ‐catalyzed Ullmann cross‐coupling of the 3‐iodopyrrole‐2‐carboxaldehyde 13 with o ‐bromonitrobenzene ( 14 ), conversion of the resulting 3‐arylpyrrole 15 into methylketone 17 , and reductive cyclization of 17 by using magnesium in methanol to give target 1 in 85 % yield.