Concepedia

3‐Chlorooxindoles: Versatile Starting Materials for Asymmetric Organocatalytic Synthesis of Spirooxindoles

Artur Noole, Maksim Ošeka, Tõnis Pehk, Mario Öeren, Ivar Järving, M.R.J. Elsegood, Andrei V. Malkov, Margus Lopp, Tõnis Kanger

Advanced Synthesis & Catalysis · 2013 · 88 citations · 19 references

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Concepts

Abstract

Abstract 3‐Chlorooxoindoles have emerged as versatile precursors in the synthesis of spirocyclopropyl oxindoles. High enantio‐ and diastereoselectivity was attained under conditions of both iminium/enamine and H‐bonding catalysis.

References

19

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

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Organocatalytic Formation of Quaternary Stereocenters

Marco Bella, Tecla Gasperi · Synthesis · 2009 · 550 citations

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Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst

Bin Tan, Nuno R. Candeias, Carlos F. Barbas · Nature Chemistry · 2011 · 466 citations

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Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Giorgio Bencivenni, Andrea Mazzanti, Berardino Giannichi et al. · Angewandte Chemie International Edition · 2009 · 447 citations

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