IEICE Transactions on Electronics · 2012 · 15 citations · 39 references
EngineeringBioengineeringBiomedical EngineeringBiosensorsPhotonicsSensorsNanosensorsOptical BiosensingOptical BiosensorsOptical SensingOptical SensorsProtein AdsorptionLaser-based BiosensingPhotonic Crystal BiosensorsPhotonic Crystal SensorsPlasmonic BiosensorsProtein BiosensingSizeSurface Plasmon Resonance BiosensorsSurface Plasmon Resonance Sensors
High-performance and low-cost sensors are critical devices for high-throughput analyses of bio-samples in medical diagnoses and life sciences. In this paper, we demonstrate photonic crystal nanolaser sensor, which detects the adsorption of biomolecules from the lasing wavelength shift. It is a promising device, which balances a high sensitivity, high resolution, small size, easy integration, simple setup and low cost. In particular with a nanoslot structure, it achieves a super-sensitivity in protein sensing whose detection limit is three orders of magnitude lower than that of standard surface-plasmon-resonance sensors. Our investigations indicate that the nanoslot acts as a protein condenser powered by the optical gradient force, which arises from the strong localization of laser mode in the nanoslot.
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S P Colowick, M D Joshi, Jagannathan et al. · 1966 · 26.2K citations
Label-Free, Single-Molecule Detection with Optical Microcavities
Andrea M. Armani, Rajan P. Kulkarni, Scott E. Fraser et al. · Science · 2007 · 1.1K citations