Enhancement of Fractionated Radiation Therapy by an Experimental Concentrated Perflubron Emulsion (<i>Oxygent</i>®) in the Lewis Lung Carcinoma

Abstract

The concentrated Perflubron emulsion, Oxygent, in combination with breathing a 95% oxygen atmosphere, significantly enhanced the response of the murine Lewis lung carcinoma to fractionated radiation therapy. Administration of 4 to 12 g PFC/kg was most effective if administered prior to each x-ray fraction, however, alternated day and even once weekly administration of 8 or 12 PFC/kg and 95% oxygen breathing with each x-ray fraction resulted in significant improvements in tumor growth delay.