Concepedia

Increased Expression of Interleukin-1 in Coronary Artery Disease With Downregulatory Effects of HMG-CoA Reductase Inhibitors

Torgun Wæhre, Arne Yndestad, Camilla Smith, Terje Haug, Siv H. Tunheim, Lars Gullestad, Stig S. Frøland, Anne Grete Semb, Pål Aukrust, Jan Kristian Damås

Circulation · 2004 · 164 citations · 17 references

DOI

Abstract

Our findings suggest that cytokines in the IL-1 family may represent therapeutic targets in CAD. The ability of statins to modulate these cytokines in an anti-inflammatory direction underscores their immunomodulatory potential.

References

17

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

Hirokazu Kirii, Tamikazu Niwa, Yasuhiro Yamada et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2003 · 733 citations · Full text

Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina

Pål Aukrust, Fredrik Müller, Thor Ueland et al. · Circulation · 1999 · 503 citations

Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events

Luigi M. Biasucci, Giovanna Liuzzo, Giamila Fantuzzi et al. · Circulation · 1999 · 484 citations · Full text

Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells

Yong‐Jian Geng, Lynne E. Henderson, Ethan B. Levesque et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1997 · 266 citations · Full text

Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

J Damås · Cardiovascular Research · 2000 · 220 citations · Full text