AIDS · 2004 · 316 citations · 4 references
Life SciencesImmunologyPharmacologyHypersensitivityImmunogeneticsPharmacogeneticsHla TypingHypersensitivity PharmacologyHypersensitivity ReactionsImmune-related Adverse EventsViral HepatitisCd4 T Cell ActivationCd4 T-cell DepletionDrug Hypersensitivity ReactionsHla Genotype AssociationsHla Risk AllelesHla-associated Adverse Drug ReactionsT-cell Dependent Immune ResponsesT-cell Mediated Immune Response
Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.
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