Journal of Reconstructive Microsurgery · 2001 · 24 citations · 0 references
DentistryBioengineeringPlastic SurgeryMicrosurgeryRegenerative MedicineTissue EngineeringAngiogenesisAnimal Tissue EngineeringFlap SurgeryFree Flap ReconstructionGrowth Factor DeliveryGrowth Factor Delivery SystemsAngiogenic Delivery SystemsFlap PhysiologyGrowth Factor Delivery MaterialsGrowth Factor Delivery ScaffoldsLatissimus Dorsi Free FlapMuscle FlapsScaffold-based Delivery SystemsSkin Graft Survival
Prefabrication of a latissimus dorsi myocutaneous flap was performed in adult male Landrace pigs. Gelfoam sponges were used as a delivery system for basic fibroblast growth factor (bFGF) at the muscle-subcutaneous tissue interface. Skin survival and angiogenesis were augmented in the growth-factor-treated animals. These data support the use of basic fibroblast growth factor to enhance flap prefabrication.