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Treatment of AIDS-Related Kaposi’s Sarcoma with Recombinant γ-Interferon
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1986
Year
Primary ImmunodeficiencyAutoimmune DiseaseProgressive DiseaseMedicineImmunodeficienciesImmunologyAntiviral TherapyPathologyAntiviral ResponseAutoimmunityRecurrent DiseaseImmunologic DiseaseChronic Viral InfectionImmunosuppressionHivImmunotherapyAcquired Immunodeficiency SyndromeRecombinant γ-Interferon
Four patients with the acquired immunodeficiency syndrome and Kaposi's sarcoma were treated with subcutaneous human recombinant gamma-interferon at a dosage of 200 micrograms = 2 X 10(6) U twice daily for at least 28 days. While the dosage of interferon was well tolerated, progressive disease was observed in all four patients studied. These results might be due to the selection of the patients presenting advanced stages (3 out of 4) with recurrent disease after previous chemotherapy.