1‐Phenyl‐6,7‐disubstituted‐aminopropyl)‐1,2,3,4‐tetrahydroisoquinolines as possible antituberculer agents

Abstract

Abstract The Condensation of 3,4‐disubstituted phenylethylamine and benzaldehyde furnished l‐phenyl‐6,7‐disubstituted‐1,2,3,4‐tetrahydroisoquinolines l. which on reaction with 1,3‐dibromopropane gave l‐phenyl‐6,7‐disubstituted‐2‐(3‐bromoprophyl)‐1,2,3,4‐tetrahydroisoquinolines 2. The reaction of 2 with different secondary amines resulted in the synthesis of 3. The compounds 3 were screened for their in vitro antituberculer activity against Mycobacterium smegmatis , and some of them have been found to be total inhibitors of M. Smegmatis