Evaluation of practolol in hypertension. Effects on sympathetic nervous system and renin responsiveness.

Abstract

The ,B-adrenergic blocker, practolol, proved to be an effective antihypertensive agent in a single-blind crossover trial, involving I7 patients with essential hypertension of mild to moderate severity. After a 2-month placebo period, dosage was begun at IOO mg twice a day, and titrated against blood pressure response up to a maximum Received 26 September 1972.