Procoagulant and Prothrombotic Responses of Human Endothelium to Indomethacin and Endotoxin in Vitro Relevance to Non-Steroidal Anti-Inflammatory Drug Enteropathy

Abstract

Indomethacin induces PCA in HUVEC and augments LPS-induced PCA, while it abolishes the antithrombotic prostanoid response in these cells. These observations may be relevant to the microvascular injury and thrombosis observed in NSAID enteropathy.