Experimental glomerulonephritis in the mouse. I. The model.

Abstract

Mice immunized with dog glomerular basement membrane in Fruend's complete adjuvant uniformly developed severe renal lesions. A prominent event in many animals appeared to be mononuclear cell accumulation around small renal blood vessels. Glomerular lesions characterized by hypercellularity, thickening of basement membrane, necrosis, and well marked crescent formation were noted. Immunofluorescent and antibody elution studies from the kidneys of animals immunized with dog GBM demonstrated the presence of specific anti-GBM antibody which could be detected in mouse glomeruli 4 weeks after initial immunization.