Deletion of the N-Terminal Domain Alters the Ethanol Inhibition of<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptors in a Subunit-Dependent Manner

Abstract

These findings indicate that the NTD modestly influences the EtOH sensitivity of NMDA receptors in a subunit-dependent manner. They also show that ifenprodil's actions on GluN2B-containing receptors can be dissociated from those of EtOH. These results suggest that while the NTD is not a primary site of action for EtOH on NMDA receptors, it likely affects sensitivity via actions on intrinsic channel properties.