Antibiotic Combinations

Abstract

SINCE the introduction of erythromycin, many antibiotics having a similar antibacterial spectrum and exhibiting crossresistance with it have been encountered in various laboratories that are conducting programs designed to discover new antimicrobial agents. Thus far, attempts to exploit such erythromycinlike agents have been made with only 3 of them. The first of these, carbomycin (Magnamycin), was soon found to have so little clinical activity as compared with erythromycin or with other available agents that its use has been almost completely abandoned.Two other new antibiotics have become available more recently: oleandomycin (PA 105, Matromycin, Romicil)1 in this country; and spiramycin . . .