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Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents
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1978
Year
Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryAntiparasitic AgentMedicineNatural SciencesAntiamebic AgentsPharmacotherapyHepatic FormsGood ActivityAntibacterial AgentAntimicrobial CompoundAntimicrobial ChemotherapyPharmacologyEntamoeba Histolytica InfectionsDrug DiscoveryDrug Resistance
A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.