Solubiliy of Sodium Cefotaxime in Aqueous 2-Propanol Mixtures

Abstract

Using a laser monitoring observation technique, the solubilities of sodium cefotaxime (A) in binary water (B) + 2-propanol (C) solvent mixtures were determined by the synthetic method from 278.15 K to 308.15 K and in the solvent composition ( ) range from 0.025 to 1.000. The results of these measurements were correlated by the combined nearly ideal binary solvent (CNIBS)/Redlich−Kister equation. For the seven mixtures studied, the CNIBS/Redlich−Kister equation was found to provide a good correlation of the experimental data.