A Convenient Domino Access to Substituted Alkyl 1,2‐Dihydropyridine‐3‐carboxylates from Propargyl Enol Ethers and Primary Amines

Abstract

All at once: Microwave irradiation of a metal-free mixture of propargyl enol ethers and primary amines generates substituted alkyl 1,2-dihydropyridine-3-carboxylates in excellent yields through a domino process (see scheme). The obtained 1,2-dihydropyridines feature four possible diversity points and a chemical handle for complexity-diversity generation (carboxylic ester at the C3 position).