1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T47e,Ion-sensitive field-effect transistors (ISFET's) have been fabricated by using silicon films on sapphire substrates (SOS). Using this structure SiO 2 , ZrO 2 , and Ta 2 O 5 films are examined as hydrogenion-sensitive materials, and Ta 2 O 5 film has been found to have the highest pH sensitivity (56 mV/pH) among them. The measured pH sensitivity of this SOS-ISFET's is compared with the theoretical sensitivity based on the site-binding model of proton dissociation reaction on the metal oxide film and good agreement between them is obtained.1e:T4a6,The feasibility of a multi-enzyme electrode for simultaneous determination of glucose and urea has been investigated. The multi-enzyme electrode consisted of three hydrogen-ion-sensitive field-effect transistors ( p H-ISFET) with a platinum wire as a pseudoreference electrode. The first p H-ISFET had an immobilized glucose oxidase (GOD) membrane, the second one had an immobilized urease membrane, and the third one had no enzyme membrane. The enzymes were immobilized by a water-soluble photocrosslinkable polymer over the pH-ISFET's, and the enzyme-photocrosslinked polymer membranes thus obtained were further hardened by the reaction of bovine serum albumin (BSA) that has been added to the enzyme-polymer mixture with glutaraldehyde. The multi-enzyme electrode can be used for determining glucose and urea over the concentration range 50-1000 mg/l. The multi-enzyme electrode was shown to be potentially promising, although it requires some improvements for practical applications.

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