Synthesis of a11C-labelled prostaglandin F2α analogue using an improved method for stille reactions with [11C]methyl iodide

Abstract

17-(3-[11C]methylphenyl)-18,19,20-trinor-PGF2αisopropyl ester 2 was synthesised using an improved method for cross-coupling reactions with [11C]methyl iodide. The decay-corrected radiochemical yield of 2 was 34 % based on [11C]methyl iodide in a synthesis time of 30 min from end of radionuclide production. The specific radioactivity was approximately 100 GBq/µmol and the radiochemical purity was higher than 95 % as determined by analytical LC. In a typical experiment 1.3 GBq of 2 was obtained from 11 GBq of [11C]methyl iodide. Copyright © 2000 John Wiley & Sons, Ltd.