OCULAR LESIONS AFTER TREATMENT WITH CHLOROQUINE

Abstract

IN 1955 one of us (H. E. H.) saw a patient in whom the complaint of haloes arose from deposits in the corneal epithelium resembling those described by Mann (1947) in workers engaged in the manufacture of atebrine. This patient was at that time under treatment for actinic dermatitis with chloroquine and the similarity of the corneal changes to those described by Mann suggested that a relationship between them and the drug might exist. Treatment was, therefore, stopped and the opacities gradually faded. The case differed from those described by Mann in the important respect that no question of external contamination of the cornea could arise and the implication that opacification of the ocular tissues could occur from drugs taken by mouth seemed of sufficient importance to warrant further FiG. I.-Keratopathy-early stage.