Clinical transplantation of<i>ex vivo</i>expanded autologous limbal epithelial cells using a culture medium with human serum as single supplement: a retrospective case series

Abstract

Our clinical study shows that patients with LSCD can be treated successfully with transplantation of LECs expanded ex vivo in a medium with autologous serum as the only growth supplement. The use of this novel culture system, which is devoid of animal-derived products and non-human/recombinant growth factors (including Cholera Toxin), reduces the risks of inter-species disease transmission and host immune responses to xenogenic proteins, both obvious advantages for the patient.