1,3‐Dipolar Cycloaddition: Click Chemistry for the Synthesis of 5‐Substituted Tetrazoles from Organoaluminum Azides and Nitriles

Abstract

Cheap and safe: Conventional methods to prepare tetrazoles employ dangerous, toxic reagents. A new route to these heterocycles (see scheme) uses inexpensive and nontoxic dialkyl aluminum azides. The cycloaddition occurs under mild conditions and tolerates a variety of functional groups. The low cost and ecocompatibility make this process attractive for large-scale preparation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701045_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.