Anesthesiology · 1970 · 100 citations · 0 references
EngineeringOrganic ChemistryBioanalysisToxicologyAnalytical ChemistryToxicological AspectClinical Chemistry14C-labeled HalothaneNuclear MedicineChromatographyLiquid Scintillation CountingBiochemistryMedicineExperimental ToxicologyPharmacologyMass SpectrometryRadioanalytical ChemistryNon-lyophilizable RadioactivityHalogenationAnesthesiologyDrug Analysis
Biotransformation of 14C-labeled halothane was studied in anesthetists and pharmacists. Halothane was administered intravenously and non-lyophilizable radioactivity assayed in urine and other excreta by liquid scintillation counting. Exhaled halothane was trapped in toluene and assayed similarly. Ur