Responses of the Skin Microcirculation to Acetylcholine in Patients with Essential Hypertension and in Normotensive Patients with Chronic Renal Failure

Abstract

The endothelium-dependent hyperemia following ACh iontophoretic delivery is impaired in the skin microcirculation of essential hypertensive patients, but this is not the case in CRF patients with no history of arterial hypertension. This suggests that CRF per se, independent of arterial hypertension, is not associated with endothelial dysfunction of skin microcirculation.