Substituierte Propargylcarbinole und ihre hypnotische Wirkung

Abstract

Abstract Thirty tertiary propargylic carbinols have been prepared by condensing propargyl bromide with ketones. Some of them showed better hypnotic activity than 3‐methylpentyn‐3‐01. The best compound of the series was 1‐chloro‐2‐chloromethylpent‐4‐yn‐2‐01 which proved to be a very effective hypnotic with a favourable therapeutic index.