Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV‐positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia

Abstract

The assumption that visible perianal warts are benign lesions in HIV-positive patients has to be reevaluated since an important number of such lesions could correspond to low-grade anal disease, which in turn could progress to high-grade anal disease or cancer. In addition, our results in this preliminary study indicate that imiquimod appears to be effective in treating AIN in HIV-positive patients. Further studies are needed to document its utility to prevent high-grade dysplasia and/or anal cancer.