Organic Letters · 2012 · 120 citations · 2 references
MedicineMicrobiologyPharmacologyDrug DiscoveryMycologyStructure-activity RelationshipsAntibacterial AgentsAntibacterial PharmacologyAntibiotic ResistanceAntifungal AgentsMarine Drug DiscoveryBioactive Compounds From Marine FungiFungal AntibioticsFungal Bioactive CompoundsFungal Drug DiscoveryMarine Fungal Natural ProductsMarine Fungi As Drug SourcesMarine-derived Antimicrobial Compounds
An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.
2
The structures of five diketopiperazines from Aspergillus ustus
P. S. STEYN · Tetrahedron · 1973 · 143 citations
Brevianamide J, A New Indole Alkaloid Dimer from Fungus<i>Aspergillus versicolor</i>
Guo‐You Li, Tao Yang, Yinggang Luo et al. · Organic Letters · 2009 · 86 citations