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An Efficient One-Pot Preparation of 2,4-Pentadienoic Esters from α,β-Unsaturated Aldehydes
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1988
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Chemical EngineeringEngineeringCatalytic AmountOrganic ChemistryRegio-and Stereoselective ProcessCatalysisStereoselective SynthesisChemistrySynthesis MethodEfficient One-pot PreparationAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineeringβ-Unsaturated Aldehydes React
α,β-Unsaturated aldehydes react with monoalkyl malonates in pyridine with a catalytic amount of dimethylaminopyridine (DMAP) in a regio-and stereoselective process to yield almost exclusively 2,4-pentadienoic esters with essentially (and in many cases exclusively) the 2E-stereochemistry.