European Journal of Endocrinology · 1979 · 13 citations · 0 references
MedicineEndocrinologyPediatricsPediatric EndocrinologyReproductive EndocrinologyReproductive PhysiologyGonadal HormonesHypothalamic-pituitary RegulationHypothalamic-pituitary-gonadal AxisPituitary HormonesPubertal DevelopmentPubertyDevelopmental Endocrinology Of PubertyGonadal PhysiologyHypothalamic Puberty RegulationHypothalamic-pituitary-gonadal Axis MaturationPubertal Hormone RegulationPubertal SteroidogenesisPuberty In BoysTestosterone Therapy
Eight boys with severely delayed puberty without pathological cause were treated for 6 months with testosterone. This resulted in acceleration of skeletal maturation and a marked increase in height and weight. No adverse effects were found on hypothalamic-pituitary and gonadal maturation. Basal LH, FSH and testosterone levels rose to nearly adult values at follow-up within a year and pituitary responsiveness to LH-RH increased markedly.